A structurally plastic ribonucleoprotein complex mediates post-transcriptional gene regulation in HIV-1
نویسندگان
چکیده
منابع مشابه
Dynamic Post-Transcriptional Regulation of HIV-1 Gene Expression
Gene expression of the human immunodeficiency virus type 1 (HIV-1) is a highly regulated process. Basal transcription of the integrated provirus generates early transcripts that encode for the viral products Tat and Rev. Tat promotes the elongation of RNA polymerase while Rev mediates the nuclear export of viral RNAs that contain the Rev-responsive RNA element (RRE). These RNAs are exported fro...
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OF THE DISSERTATION ........................................................................... ii DEDICATION .................................................................................................................... v LIST OF FIGURES AND TABLES.................................................................................. ix ACKNOWLEDGMENTS ...........................................
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Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat stimulates transcription elongation by directing the cellular transcriptional elongation factor P-TEFb to nascent RNA polymerases. Rev is required for the transport from the nucleus to the cytoplasm of the unspliced and incompletely spliced mRNAs that encode the structural proteins of the virus. Molecula...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: RNA
سال: 2016
ISSN: 1757-7004
DOI: 10.1002/wrna.1342